Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Hypoparathyroidism

Treatments: Biological: immediate post operative bioassay of Parathyroid Hormone

Study type: Observational

Funder types: Other

Identifiers

NCT02924532

LOCAL/2014/BL-01

Details and patient eligibility

About

The main objective of this study is to establish an optimal threshold Early parathormon (PTH) assay in order to exclude hypoparathyroidism , that is to say to obtain a negative predictive value of hypoparathyroidism highest possible.

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients consecutively operated on between February 1, 2012 and December 1, 2013
• Total thyroidectomy +/- lymphadenectomy
• Respect of clinicobiological protocol presented above
• The ( the ) patient ( e) was informed ( e) on the implementation of the study 's objectives, constraints and patient rights
• The ( the ) patient ( e) is under ( e) at least 18 years

Exclusion criteria

• The ( the ) patient ( e) is under guardianship, curatorship or under guard saves justice
• It is not possible to give to ( the ) patient ( e) informed information
• History of cervical radiotherapy
• Previous history of dysfunction of the parathyroid glands
• Previous history of surgery of the parathyroid glands
• A history of kidney failure or hepatocellular
• History of osteomalacia or Paget's disease
• unhealed cancer antecedent
• History of sarcoidosis

Trial design

300 participants in 1 patient group

Patients with total thiroidectomy

Treatment:

Biological: immediate post operative bioassay of Parathyroid Hormone