Postoperative Effects of Propofol Versus Sevoflurane Anesthesia

Damanhour Teaching Hospital

Status and phase: Completed; Phase 4

Conditions: General Anesthetic Drug Adverse Reaction

Treatments: Drug: Propofol 10 MG/ML Injection; Drug: Sevoflurane Inhalation Liquid

Study type: Interventional

Funder types: Other

Identifiers

NCT05935930

DTH: 22004

Details and patient eligibility

About

Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.

Objectives: To compare the efficacy and safety of propofol versus sevoflurane in patients undergoing elective, non-cardiac operations under general anesthesia.

Methods: This was a randomized (1:1), parallel, phase four clinical trial; carried out on 44 patients, who were candidates for elective, non-cardiac operations under general anesthesia at our hospital. Patients were randomly allocated into two equal groups in which anesthesia was maintained with propofol infusion in group P and sevoflurane inhalation in group S.

Enrollment: 44 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status ≤ II
• Age from 21 years
• Body Mass Index (BMI) 25-35 kg/m2

Exclusion criteria

• ASA physical status > II
• Age < 21 years
• Patients with Montreal Objective Cognitive Assessment (MoCA-B) score < 24 points
• Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases
• Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia
• Patients on long-term use of sedatives or steroids, alcohol or drug abuse
• Allergy to any of the study drugs

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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44 participants in 2 patient groups

Group P (n=22)

Active Comparator group

Description:

Propofol group

Treatment:

Drug: Propofol 10 MG/ML Injection

Group S (n=22)

Active Comparator group

Description:

Sevoflurane group

Treatment:

Drug: Sevoflurane Inhalation Liquid