Postoperative Lactate and Atrial Fibrillation After CABG

Başakşehir Çam & Sakura City Hospital

Status: Enrolling

Conditions: Coronary Artery Disease; Atrial Fibrillation

Study type: Observational

Funder types: Other

Identifiers

NCT05448521

KAEK/2021.12.289

Details and patient eligibility

About

Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG). It has been estimated that 5-40% of CABG patients experience POAF. Advanced age, P wave abnormalities, left atrial dilation, emergency surgery, low left ventricle ejection fraction, low glomerular filtration rate and chronic obstructive pulmonary disease have been reported in the etiology. Predicting which patients would experience POAF following CABG is important since it would allow physicians to apply more focused prophylactic measures. Lactate is the final product of anaerobic glycolysis. Serum lactate level are increased in case of inadequate oxygen delivery to tissues. The investigators aim to assess whether serum lactate levels measured early in the postoperative period could be used as a predictive marker of POAF in adults undergoing isolated CABG.

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing isolated CABG
• Age >18 years

Exclusion criteria

• Age <18 years
• Pregnancy
• History of paroxysmal atrial fibrillation prior to surgery
• Undergoing concomitant procedures (e.g., CABG + valve surgery)
• Any preoperative cardiac rhythm other than normal sinus rhythm
• More than mild cardiac valve stenosis or insufficiency

Trial design

250 participants in 2 patient groups

Low lactate

Description:

Patients with a low lactate level defined by logistic regression analysis.

High lactate

Description:

Patients with a high lactate level defined by logistic regression analysis.