Postoperative Nausea and Vomiting: Ramosetron Plus Aprepitant vs Palonosetron Plus Aprepitant

Kyungpook National University

Status: Completed

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Ramosetron; Drug: palonosetron; Drug: aprepitant

Study type: Interventional

Funder types: Other

Identifiers

NCT02597907

KNUH 2014-05-016

Details and patient eligibility

About

The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.

Full description

The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.

Study is performed during 24 hours after surgery.

Enrollment: 88 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non smoking, female patients, scheduled for laparoscopic cholecystectomy

Exclusion criteria

• Patients with gastrointestinal disorder,
• Patients with allergies to any study medication,
• Patients who had received any sedatives, opioid, steroid or antiemetics within 24 h before surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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88 participants in 2 patient groups

aprepitant plus palonosetron

Experimental group

Description:

aprepitant 80 mg palonosetron 0.075 mg

Treatment:

Drug: aprepitant

Drug: palonosetron

aprepitant plus ramosetron

Active Comparator group

Description:

aprepitant 80 mg ramosetron 0.3 mg

Treatment:

Drug: Ramosetron

Drug: aprepitant