Postoperative Pain and Discomfort After Orbital Decompression

Sun Yat-sen University

Status: Completed

Conditions: Surgery; Pain; Anesthesia

Treatments: Drug: Nalbuphine; Drug: Nalbuphine and Flurbiprofen Axetil; Drug: Flurbiprofen Axetil

Study type: Interventional

Funder types: Other

Identifiers

NCT03562611

201806

Details and patient eligibility

About

The purpose of this study is to evaluate the postoperative pain and discomfort using flurbiprofen axetil or nalbuphine administration after orbital decompression under general anesthesia.

Full description

To investigate postoperative analgesia achieved with intraoperative administration of intravenous nalbuphine and flurbiprofen axetil in patients undergoing orbital decompression

Enrollment: 63 patients

Sex: All

Ages: 16 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 16-75 years old
• diagnosed as thyroid eye disease
• bone removal orbital decompression under general anesthesia
• American Society of Anesthesiologists (ASA) physical status of I-II

Exclusion criteria

• body mass index (BMI) <18.5 or >35
• any uncontrolled clinical problems

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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63 participants in 3 patient groups

flurbiprofen axetil

Active Comparator group

Description:

flurbiprofen axetil intraoperative administration 100mg

Treatment:

Drug: Flurbiprofen Axetil

nalbuphine

Experimental group

Description:

nalbuphine intraoperative administration 0.1mg/kg

Treatment:

Drug: Nalbuphine

nalbuphine and flurbiprofen axetil

Experimental group

Description:

flurbiprofen axetil intraoperative administration 100mg and nalbuphine intraoperative administration 0.1mg/kg

Treatment:

Drug: Nalbuphine and Flurbiprofen Axetil