Postoperative Pain Evaluation After Obturation With Different Sealers

University of Siena

Status: Enrolling

Conditions: Pulpitis; Periapical Periodontitis; Necorsis

Treatments: Procedure: Continuous Wave Condensation; Procedure: AH Plus (Dentsply Sirona, Charlotte, NC, USA); Procedure: NeoSealer Flo; Procedure: Single Cone Technique

Study type: Interventional

Funder types: Other

Identifiers

NCT07018284

HSCO

Details and patient eligibility

About

This study aims to evaluate the incidence and intensity of postoperative pain in patients undergoing root canal treatment on teeth diagnosed with pulpitis, pulp necrosis, or with previous endodontic treatment. Teeth will be obturated using either bioceramic or resin-based sealers. The primary objective is to determine whether the type of sealer significantly influences the level of postoperative pain as reported by patients. Pain intensity will be assessed using the Visual Analogue Scale (VAS) at three time points: immediately after treatment, 24 hours, and 72 hours postoperatively. The findings are expected to provide clinical insight into which obturation material may be more effective in minimizing postoperative discomfort.

Enrollment: 270 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage.

Exclusion criteria

• Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression).
• Asymptomatic presentation
• Teeth with root fractures, resorption, or open apices.
• Incomplete clinical or radiographic records.
• Cases with poor-quality radiographs or lack of standardization for evaluation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

270 participants in 4 patient groups

Active Comparator: AH Plus + Continuous Wave Condensation

Active Comparator group

Description:

Root canal obturation using AH Plus (Dentsply Sirona, Charlotte, NC, USA) and the continuous wave technique with thermoplasticized gutta-percha

Treatment:

Procedure: AH Plus (Dentsply Sirona, Charlotte, NC, USA)

Procedure: Continuous Wave Condensation

Active Comparator: AH Plus + Single Cone

Experimental group

Description:

Root canal obturation using AH Plus and the single cone technique with cold gutta-percha.

Treatment:

Procedure: Single Cone Technique

Procedure: AH Plus (Dentsply Sirona, Charlotte, NC, USA)

NeoSealer Flo + Continuous Wave

Experimental group

Description:

Root canal obturation using NeoSealer Flo (Avalon Biomed, Houston, TX, USA) and the continuous wave technique.

Treatment:

Procedure: NeoSealer Flo

Procedure: Continuous Wave Condensation

NeoSealer Flo + Single Cone

Experimental group

Description:

Root canal obturation using NeoSealer Flo and the single cone technique.

Treatment:

Procedure: Single Cone Technique

Procedure: NeoSealer Flo