Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics (KNEE BDNF)

University Hospital Center (CHU)

Status: Completed

Conditions: Chronic Postoperative Pain; Total Knee Arthroplasty

Treatments: Diagnostic Test: blood test

Study type: Interventional

Funder types: Other

Identifiers

NCT04604847

RECHMPL19_0192

Details and patient eligibility

About

Chronic pain is an extremely disabling disease. It is a major public health problem due to the lack of effective therapy.

Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to previous pain, present for more than 3 months, and without any link to surgical complication.

The prevalence of chronicization of postoperative pain is 30% after total knee arthroplasty.

Identification of clinical, biological and psychological profiles are crucial to prevent CPOP.

A biologic factor, Brain Derived Neurotrophic Factor (BDNF) produced by a variety of cells is a key regulator of neuroplasticity. BDNF is increasingly studied in the mechanisms of cerebral sensitization and pain chronicization. The role of BDNF in pain of patients remains to be explored in a prospective study. The aim of this observational study is to compare the kinetics of BDNF after total knee arthroplasty in patients with and without CPOP.

Patients will be included in the study at the preanesthetic consultation. Serum BDNF levels will be measured preoperatively, 48h postoperatively, 3 and 6 months after surgery.

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Social security affiliation
• Adult patients
• Signed informed consent
• Score ASA (American Society of Anesthesiology) 1-3
• Total knee arthroplasty

Exclusion criteria

• Patient unable to exercise consent
• Pregnant women
• Vulnerable people
• Patients not included in the postoperative rehabilitation program
• Patients unable to complete the pain assessment questionnaires
• Chronic pain patients (other than knee arthrosis)
• Neuropathic pain patients (beforehand)
• Inflammatory diseases, progressive cancer, sepsis, immunosuppression known

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 1 patient group

Total knee arthroplasty

Other group

Description:

patient operated for a total knee arthroplasty

Treatment:

Diagnostic Test: blood test