Postoperative Quality of Recovery After Transurethral Resection of the Bladder

General Hospital Zadar

Status: Unknown

Conditions: Postoperative Recovery; Urinary Bladder Neoplasms; Transurethral Resection of the Bladder

Treatments: Drug: bupivacaine; Drug: propofol; Procedure: Spinal anesthesia; Drug: fentanyl; Procedure: General anesthesia; Drug: sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02534623

GHZ trial 001

Details and patient eligibility

About

Transurethral resection of the bladder (TURB) is often performed as an outpatient procedure so high-quality postoperative recovery is particularly important. The aim of this study is to compare postoperative quality of recovery after spinal anesthesia (SA) and general anesthesia (GA) for transurethral resection of the bladder.

Full description

After written informed consent is obtained seventy patients aged 18-80 years, ASA (American Society of Anesthesiologists) physical status class I-III scheduled for TURB will be randomly assigned to either spinal anesthesia or general anesthesia. Spinal anesthesia will be performed with 12.5 mg of bupivacaine mixed with 25 mcg of fentanyl. General anesthesia will be performed with propofol and fentanyl and maintained with sevoflurane, without use of neuromuscular blocking agents. Quality of Recovery 40 questionnaire (QoR-40) administered before and 24 hours after surgery will be used for assessment of postoperative recovery.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Transurethral resection of the bladder
• Age 18 to 80 years
• ASA I-III

Exclusion criteria

• Contraindications for spinal anesthesia
• Chronic pain with use of opioids in the last week
• Psychiatric disorders
• Allergy to medications used in the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

70 participants in 2 patient groups

Spinal anesthesia

Active Comparator group

Description:

Transurethral resection of the bladder performed under spinal anesthesia.

Treatment:

Procedure: Spinal anesthesia

Drug: fentanyl

Drug: bupivacaine

General anesthesia

Active Comparator group

Description:

Transurethral resection of the bladder performed under general anesthesia.

Treatment:

Drug: sevoflurane

Drug: propofol

Procedure: General anesthesia

Drug: fentanyl