Postoperative Safety Outcomes of Intraoperative Intracameral Preservative-Free Moxifloxacin Versus Levofloxacin

Peregrine Eye and Laser Institute

Status and phase: Completed; Phase 4

Conditions: Antibiotic Side Effect; Cataract Senile; Endophthalmitis; Safety Issues

Treatments: Drug: Moxifloxacin Ophthalmic; Drug: Levofloxacin Ophthalmic

Study type: Interventional

Funder types: Other

Identifiers

NCT04403334

20180101

Details and patient eligibility

About

Comparative safety study of intracameral levofloxacin versus moxifloxacin for postoperative infection prophylaxis

Full description

Randomized clinical trial comparing corneal and retinal changes after intracameral levofloxacin or moxifloxacin administered at the end of surgery among eyes undergoing uncomplicated phacoemulsification.

Enrollment: 114 patients

Sex: All

Ages: 21 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Eyes undergoing uncomplicated cataract surgery by phacoemulsification

Exclusion criteria

• Corneal opacities, corneal dystrophies, glaucoma, uveitis, retinopathy, optic neuropathy, concomitant infection (blepharitis, hordeolum, or conjunctivitis) or uncontrolled systemic disease and intraoperative complications that may affect visual outcomes were excluded from the study

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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114 participants in 2 patient groups

Intracameral levofloxacin

Experimental group

Description:

0.5% unpreserved solution

Treatment:

Drug: Levofloxacin Ophthalmic

Intracameral moxifloxacin

Experimental group

Description:

0.5% unpreserved solution

Treatment:

Drug: Moxifloxacin Ophthalmic