Postoperative Sleep Disturbances After Zolpidem Treatment in Fast-track Hip and Knee Replacement

Rigshospitalet

Status: Unknown

Conditions: Sleep Duration on the First Night After Surgery

Treatments: Drug: Placebo; Drug: Zolpidem

Study type: Interventional

Funder types: Other

Identifiers

NCT01551485

H-3-2011-022

Details and patient eligibility

About

Sleep after surgery has been found to be very distrubed immediately after major surgery. This is also seen after fast-track hip and knee replacement with length of stay of less than 3 days. Disturbed sleep has many adverse effects i.e. fatigue, possible hyperalgesia and decline in cognitive abilities.

Enrollment: 20 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Total hip or knee replacement in fast-track setup
• Age 60 years or above
• ASA class 1-3

Exclusion criteria

• Anesthesia within the pas 30 days
• Daily use of alcohol > 21 units / week
• Use of anxiolytics or hypnotics within the past 30 days
• Inability to read and understand Danish
• Marked reduction of sight or hearing
• Parkinson's disease or other neurological disaese causing function deficits
• Inability to cooperate to sleep monitoring
• allergy to the drug tested

Trial design

20 participants in 2 patient groups, including a placebo group

Zolpidem

Experimental group

Treatment:

Drug: Zolpidem

Placebo

Placebo Comparator group

Treatment:

Drug: Placebo