Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management

China Medical University, China

Status and phase: Completed; Phase 4

Conditions: General Anesthesia, Thoracic Epidural Anesthesia

Treatments: Procedure: general anesthesia combined with TEA; Drug: general anesthesia combined with dexmedetomidine infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT01725607

20121101

Details and patient eligibility

About

We designed a study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

Full description

We designed a prospective, single-blinded, randomized, and controlled study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

Enrollment: 219 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• lung surgery
• one-lung ventilation.

Exclusion criteria

• body mass index exceeding 30 kg/m2,
• autonomic dysfunction,
• cardiovascular disease,
• neurological or psychiatric diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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219 participants in 3 patient groups

the control group (Group C)

No Intervention group

Description:

general anesthesia

general anesthesia combined with dexmedetomidine infusion

Experimental group

Description:

general anesthesia combined with 1 μg/kg dexmedetomidine infusion after induction (Group D)

Treatment:

Drug: general anesthesia combined with dexmedetomidine infusion

general anesthesia combined with TEA

Experimental group

Description:

general anesthesia combined with TEA (Group E)

Treatment:

Procedure: general anesthesia combined with TEA