Postoperative VEGF and Recurrence After Colon Cancer Surgery

Hospital del Mar

Status: Unknown

Conditions: Surgery; Colon Cancer; Angiogenesis; VEGF Overexpression; Recurrence

Treatments: Procedure: Surgery for colon cancer with intention to cure

Study type: Observational

Funder types: Other

Identifiers

NCT04851054

2015/6097/I

Details and patient eligibility

About

The purpose of this trial is to study the relationship between the angiogenic response to surgical aggression, determined through the serum levels of vascular endothelial growth factor (VEGF) on postoperative day four, and the tumor recurrence in patients with colon cancer operated with a curative intention.

Full description

DESIGN: Prospective multicentric study.

PARTICIPATION: Colorectal Surgery Units of Hospital del Mar, Barcelona; Hospital Universitari Joan XXIII, Tarragona; Hospital Universitari La Fe, Valencia; Hospital Clínico San Carlos, Madrid; Hospital General de Granollers, Granollers; Hospital Germans Trias i Pujol, Badalona; Athalaia, Xarxa Assistencial Universitària de Manresa, Manresa

STUDY SUBJECTS: 280 consecutive patients with non-metastatic colon cancer in whom a curative intent resection is performed.

DETERMINATIONS: Determination of the proangiogenic cytokine VEGF in serum on the postoperative day four to assess its relationship with oncological results on long-term follow-up.

Enrollment: 280 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with colon cancer admitted to the Colorectal Surgery Unit of the centers participating in the study,
• Patients who will undergo elective surgical resection with potentially curative intention

Exclusion criteria

• Patients with metastatic disease
• Patients with synchronous colon neoplasia or in the previous five years
• Patients undergoing emergency surgery
• Patients who do not sign the informed consent.

Trial design

280 participants in 1 patient group

Patients after surgery for colon cancer with intention to cure

Description:

Patients with colon cancer admitted to the Colorectal Surgery Unit of the centers participating in the study, who will undergo elective surgical resection with potentially curative intention

Treatment:

Procedure: Surgery for colon cancer with intention to cure