Postpartum Outcomes in BC

University of British Columbia

Status: Active, not recruiting

Conditions: Morbidity;Perinatal; Pregnancy Complications; Pregnancy Related

Treatments: Other: Retrospective database analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05461183

H21-01696

Details and patient eligibility

About

For every case of maternal death, many more women experience life-threatening complications during pregnancy and childbirth. Yet, severe maternal morbidity (SMM) cases are often overlooked post-delivery. Women have reported that roughly 15% of SMM cases first occurred in the six weeks following delivery. The underlying factors associated with these morbidities are likely different than those occurring antenatally and at the time of delivery. Further research is required to elucidate the exact burden of SMM in the postpartum period in British Columbia (BC).

Full description

The ratio of maternal morbidity to maternal mortality is increasing globally (Geller 2018). In high-income countries, the World Health Organization (WHO) recommends routinely surveilling SMM to assess maternal health and quality of care (Geller 2018). To our knowledge, this is the first study conducted among pregnancies in BC aiming to examine the cumulative incidence, timing, and factors associated with postpartum maternal morbidity and hospital readmissions.

This is a retrospective cohort study will use data from the BC Perinatal Data Registry (BCPDR), which contains maternal, fetal and neonatal health information from 99% of all deliveries in BC. The primary outcome assessed will be the cumulative incidence of hospital readmissions and SMM events occurring after delivery discharge within the first six weeks (42 days) of delivery. Secondary outcomes will include SMM-diagnosis, the rate and timing of postpartum SMM and readmissions, and maternal characteristics associated with these events. A multinominal logistic regression model will examine the association between postpartum SMM or readmission and determinants.

Enrollment: 15,000 estimated patients

Sex: Female

Ages: 15 to 49 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Delivered in BC from April 1, 2008 to March 31, 2021
• Consented to data collected by the BCPDR

Exclusion criteria

• None

Trial design

15,000 participants in 3 patient groups

Readmission/ SMM post-delivery discharge

Description:

All women aged 15-49 who were readmitted up to six weeks post-delivery discharge and/or experienced at least one SMM event up to six weeks post-delivery

Treatment:

Other: Retrospective database analysis

De novo readmission/ SMM post-delivery discharge

Description:

All women aged 15-49 who were readmitted up to six weeks post-delivery discharge and/or experienced at least one SMM event post-delivery, excluding those who experienced a SMM in the two months before delivery or during delivery hospitalization

Treatment:

Other: Retrospective database analysis

No post-delivery discharge readmission/ SMM at any time (CONTROL)

Description:

All women aged 15-49 who did not experience post-delivery discharge readmission and/or SMM at any time

Treatment:

Other: Retrospective database analysis