Postpartum Screening of Type 2 Diabetes (Tot ou tard)

Université de Sherbrooke

Status

Completed

Conditions

Type 2 Diabetes

Treatments

Procedure: oral glucose tolerance test 2 days post-partum

Study type

Interventional

Funder types

Other

Identifiers

NCT01869608

13-005

Details and patient eligibility

About

Gestational diabetes mellitus (GDM) complicates 5 to 30 % of pregnancies. GDM is defined as hyperglycemia with onset or first recognition during pregnancy. Because it is a forerunner of type 2 diabetes mellitus (T2DM), professional associations recommend T2DM postpartum screening (T2DM-pPS) at 6 weeks/6 months post delivery, using a 75g oral glucose tolerance test (OGTT).

However, less than a quarter of these women are screened. This recommendation has failed for multiple reasons; the most important being that busy new mothers must deal with the major inconveniences of returning to a sampling center for a 2h testing session, bringing baby along or paying for a sitter, transportation, parking... A mother-friendly solution is direly needed.

The investigators hypothesize that, in these women, results of an OGTT performed after delivery on the last day of their hospital stay (OGTT-1) will predict results of the recommended OGTT (OGTT-2) at 6 weeks/6 months postpartum.

The main aim of our project is to determine the optimal cut-off value for the 2h glucose result during OGTT-1 in order to predict abnormal glucose tolerance status at OGTT-2 (the gold standard), in the same woman.

Enrollment

121 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Women aged between 18 and 45 years;
Having a positive diagnosis of gestational diabetes mellitus (IADPSG criteria);
Treated with diet or insulin;
Have given birth to a child at term; gestational age > 37 weeks;
Have been followed during her pregnancy by a physician who delivers in CHUS;
Have signed the consent form.

Exclusion criteria

History of glucose intolerance or diabetes before the pregnancy;
Have presented another obstetrical pathology during the pregnancy;
- Severe gestational high blood pressure with proteinuria;
- Delayed intrauterine development syndrome;
- Pregnancy with more than a foetus;
- Drug addiction;
- Had complications during the delivery such as:
Moderate to severe postpartum bleeding;
Surgery in postpartum (curettage, hysterectomy, etc.).