Postpartum Uterine Curettage in the Recovery From Preeclampsia/Eclampsia

Saint Thomas Hospital (HST)

Status: Completed

Conditions: Pre-Eclampsia; Eclampsia

Treatments: Procedure: Placebo; Procedure: Curettage

Study type: Interventional

Funder types: Other

Identifiers

NCT03028194

MHST2014-06

Details and patient eligibility

About

Use of Postpartum uterine curettage in reducing hospitalization time or in improving the clinical evolution of the patient with preeclampsia/eclampsia.

Full description

To evaluate if postpartum uterine curettage improved the clinical and laboratory parameters in patients with preeclampsia or eclampsia.

A total of 442 patients with preeclampsia/eclampsia were randomized to postpartum curettage (223) or no procedure (219). Systolic and diastolic blood pressure were recorded and analyzed at hours 6, 12, 24 and 48. Also, several laboratory values and diuresis were evaluated.

Enrollment: 442 patients

Sex: Female

Ages: 15 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gestational age 24 weeks or more.
• Preeclampsia/eclampsia

Exclusion criteria

• Epilepsy or seizures previous to pregnancy.
• Renal disease
• Heart disease
• Liver disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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442 participants in 2 patient groups, including a placebo group

Curettage

Experimental group

Description:

Postpartum uterine curettage performed immediately after delivery of the placenta.

Treatment:

Procedure: Curettage

Placebo

Placebo Comparator group

Description:

No procedure performed after delivery of the placenta.

Treatment:

Procedure: Placebo