Postprandial Blood Amino Acid Response (PARROT-2)

NIZO Food Research

Status

Completed

Conditions

Protein Digestion Kinetics

Treatments

Dietary Supplement: Ca-caseinate

Dietary Supplement: 50%whey-50% casein (Standard)

Dietary Supplement: Milk protein isolate

Dietary Supplement: UHT milk

Dietary Supplement: 50%whey-50% casein (Alternative)

Dietary Supplement: Micellar Casein Isolate - Na-caseinate

Dietary Supplement: Recombined milk

Dietary Supplement: Micellar Casein Isolate

Dietary Supplement: Recombined 50%whey milk

Dietary Supplement: Micellar Casein Isolate- WPH

Dietary Supplement: Yoghurt

Dietary Supplement: Whey protein concentrate

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT03313791

NIZO175 (Other Identifier)

NL62458.072.17

Details and patient eligibility

About

This study was designed to obtain information about the change in postprandial amino acids in blood over time, after consumption of different dairy products with varying proportions of whey protein and caseins, and different processing conditions.

Enrollment

10 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18-65y
BMI 18.5-30 kg/m2
Non-smoking
Healthy as assessed by the NIZO lifestyle and health questionnaire ("Verklaring leefgewoonten en gezondheid") and according to the judgment of the study physician.".
Regular and normal Dutch eating habits as assessed by the NIZO lifestyle and health questionnaire (3 main meals per day)
Veins suitable for cannulation (blood sampling)
Voluntary participation
Having given written informed consent
Willing to comply with study procedures
Accept use of all encoded data, including publication, and the confidential use and storage of all data for 15 years.
Accept disclosure of the financial benefit of participation in the study to the authorities concerned

Exclusion criteria

Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before Day 01 of this study
Having a history of medical or surgical events that may significantly affect the study outcome, including: Inflammatory bowel disease, hepatitis, pancreatitis, ulcers, gastrointestinal or rectal bleeding; major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy, or bowel resection; known or suspected gastrointestinal disorders, colon or GI tract cancer
Use of the following medication: glucose lowering drugs, insulin; medication that may impact gastric emptying (e.g. gastric acid inhibitors or laxatives)
Diagnosed with diabetes, being treated for high blood glucose or increased fasting blood glucose (> 7 mmol/l in finger prick blood) as assessed during screening visit
For men: Hb <8,5 mmol/l as assessed during screening visit; for women: Hb <7,5 mmol/l.
Use of protein supplements
Mental status that is incompatible with the proper conduct of the study
A self-reported reported food allergy or sensitivity to dairy ingredients
Alcohol consumption for men > 28 units/week and >4/day; for women: >21 units/week and >3/day
Reported weight loss or weight gain of > 3 kg in the month prior to pre-study screening, or intention to lose weight during the study period
Reported slimming or medically prescribed diet
Recent blood donation (<1 month prior to Day 01 of the study)
Not willing or afraid to give up blood donation during the study
Personnel of NIZO food research, FrieslandCampina Research, or Wageningen University, department of Human Nutrition, their partner and their first and second degree relatives
Not having a general practitioner
Not willing to accept information-transfer concerning participation in the study, or information regarding his/her health, like laboratory results and eventual adverse events to and from his general practitioner
Self reported pregnancy or breastfeeding

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

10 participants in 12 patient groups

Whey protein concentrate

Experimental group

Description: