Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal

Agroscope Liebefeld-Posieux Research Station ALP

Status: Completed

Conditions: Nutritional Intervention; Obesity

Treatments: Other: high-fat meal C; Other: high-fat meal B; Other: high-fat meal A

Study type: Interventional

Funder types: Other

Identifiers

NCT01995110

NUTRICHIP-1-transcriptome

Details and patient eligibility

About

The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.

Enrollment: 14 patients

Sex: Male

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for normal weight subjects:

• age 25-50
• 20<BMI>25
• waist circumference <94cm

Inclusion Criteria for obese subjects:

• age 25-50
• 30<BMI>40
• waist circumference >102cm

Exclusion Criteria for both groups:

• physiological or psychological diseases
• allergies to food or intolerance to high-fat meal
• vegetarians, vegans
• chronic intake of drugs
• smokers
• diabetes mellitus type I and II
• debiliating kidney disease
• debiliating liver disease
• clinically established coronary heart diseases
• ingestion of vitamins or dietary supplements during the course of the study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 2 patient groups

normal weight subjects

Experimental group

Treatment:

Other: high-fat meal B

Other: high-fat meal A

Other: high-fat meal C

obese subjects

Experimental group

Treatment:

Other: high-fat meal B

Other: high-fat meal A

Other: high-fat meal C