Postprandial Effect of High-starch Meals in Individuals With Low and High Copy Number of the Salivary Amylase Gene

Lund University

Status: Completed

Conditions: Postprandial Glucose and Insulin Response

Treatments: Other: 40 grams of starch; Other: 80 grams of starch

Study type: Interventional

Funder types: Other

Identifiers

NCT03974126

Dnr 2018/968

Details and patient eligibility

About

Individuals with low copy numbers of salivary amylase gene have lower salivary amylase levels and might therefore have decreased capacity to metabolize starch into glucose. We will in a randomized crossover meal study examine the postprandial response of high-starch meals in individuals with either low or high copy number of the salivary amylase gene.

Enrollment: 23 patients

Sex: All

Ages: 25 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participant in the Malmö Offspring Study
• Genotyped for AMY1 copy number variation and selected for having either low (2-4) or high (10 or above) copy number of AMY1
• Gender: both males and females
• Completed information on dietary habits

Exclusion criteria

• Allergic to wheat, gluten intolerant or on a low-carbohydrate diet
• Inability to eat up to 4 slices of white bread in 15 minutes
• Use of medication known to influence glucose metabolism, appetite or saliva flow
• Diagnosed diabetes or high fasting plasma glucose (above 6.1 mmol/L)
• Smoking

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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23 participants in 2 patient groups

40 grams of starch to low and high AMY1 copy number carriers

Experimental group

Description:

The postprandial response between individuals that are either carriers of low AMY1 copy numbers (2-4) or high copy numbers (10 or more copies) will be compared

Treatment:

Other: 40 grams of starch

80 grams of starch to low and high AMY1 copy number carriers

Experimental group

Description:

The postprandial response between individuals that are either carriers of low AMY1 copy numbers (2-4) or high copy numbers (10 or more copies) will be compared

Treatment:

Other: 80 grams of starch