Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects

Lund University

Status: Completed

Conditions: Healthy

Treatments: Other: High fat challenge breakfast; Other: High fat challenge breakfast with mixed-spices

Study type: Interventional

Funder types: Other

Identifiers

NCT02931643

LUND-AFCSTAGE4-SPICEMULTIOMICS

Details and patient eligibility

About

This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the postprandial phase in healthy human subjects.

Enrollment: 18 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males and females
• BMI 23-33 kg/m2
• Must be able to accept spices
• Agreed and signed informed consent

Exclusion criteria

• Below 18 years old
• Uncomfortable speaking English and/or difficulties in understanding spoken English
• Smoking or using snuss
• Vegetarian or vegan
• Having food allergies
• Stressed by venous blood sampling or previous experience of being difficult to be cannulated
• Receiving any drug treatment that may influence the study outcomes
• Pregnancy or breastfeeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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18 participants in 2 patient groups, including a placebo group

High fat challenge breakfast

Placebo Comparator group

Description:

High fat breakfast without mixed-spices (% Energy Carbohydrate:Fat:Prot / 20:60:20), acute study / one time administration

Treatment:

Other: High fat challenge breakfast

High fat challenge breakfast with mixed-spices

Experimental group

Description:

High fat breakfast with mixed-spices (% Energy Carbohydrate:Fat:Prot / 20:60:20), acute study / one time administration

Treatment:

Other: High fat challenge breakfast with mixed-spices