Postprandial Insulin Secretion, Oxidative Stress and Gastrointestinal Peptides in Patients With Type 2 Diabetes Versus Healthy Subjects

Institute for Clinical and Experimental Medicine

Status: Completed

Conditions: Type 2 Diabetes; Postprandial Oxidative Stress

Treatments: Other: Cous-cous sandwich; Other: McCountry sandwich (McDonald's); Other: Bagueutte Cheese Gourmet (Crocodille)

Study type: Interventional

Funder types: Other

Identifiers

NCT01572402

5206

Details and patient eligibility

About

Insulin secretion, plasma lipids, oxidative stress markers and gastrointestinal peptides will be measured in patients with type 2 diabetes versus healthy subjects in a fasting status and in response to standard meals (at times 0', 30', 60', 120' and 180').

Enrollment: 100 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 40 individuals with type 2 diabetes treated by diet only or oral hypogylycemic agents,
• diabetes duration at least 1 year,
• both men and women,
• age 30-65 years,
• BMI 27-50 kg/m². The subjects will be explained aims, methods and risks of the study and they will sign informed consent

Exclusion criteria

• gravidity,
• lactation,
• drug abuse,
• insulin therapy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Patients with type 2 diabetes

Experimental group

Description:

Study group: 40 individuals with type 2 diabetes treated by diet and/or oral hypogylycemic agents, diabetes duration at least 1 year, both men and women, age 30-65 years, BMI 27-50 kg/m². The subjects will be explained aims, methods and risks of the study and they will sign informed consent

Treatment:

Other: Cous-cous sandwich

Other: Bagueutte Cheese Gourmet (Crocodille)

Other: McCountry sandwich (McDonald's)

Healthy subjects

Active Comparator group

Description:

Mean and women, age 30-70 years, no diabetes, no metabolic syndrome

Treatment:

Other: Cous-cous sandwich

Other: Bagueutte Cheese Gourmet (Crocodille)

Other: McCountry sandwich (McDonald's)