Postprandial Lipemia and Glycemia Following a High-Fat Meal

University at Buffalo (UB)

Status: Completed

Conditions: Lipid Disorder; Postprandial Hyperglycemia; Hypercholesterolemia

Treatments: Dietary Supplement: Mushroom Powder

Study type: Interventional

Funder types: Other

Identifiers

NCT05619952

030-614292

Details and patient eligibility

About

The goal of this clinical trial is to determine the acute effects on postprandial lipemia and glycemia by supplementing a high-fat meal with either white button (WB) or shiitake (SH) mushroom powder in relatively healthy adults, aged 18 to 35.

Enrollment: 16 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• generally healthy
• non-diabetic
• normal to mildly hypercholesterolemic (Total Cholesterol 200-239 mg/dL and LDL-C 130-159 mg/dL)
• have BMI <30 or BF% (men <25%, women <32%)
• no known disease of the liver or gallbladder
• no documented problems with fat metabolism
• normal lipemic response to a lipid challenge
• No known mushroom allergy

Exclusion criteria

• diabetic
• pregnant
• BMI >30
• liver disease
• gallbladder disease
• mushroom allergy
• lipid disorder

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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16 participants in 3 patient groups

White Button Mushroom

Experimental group

Description:

368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams white button mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun

Treatment:

Dietary Supplement: Mushroom Powder

Shiitake Mushroom

Experimental group

Description:

368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams Shiitake mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun

Treatment:

Dietary Supplement: Mushroom Powder

Control

No Intervention group

Description:

368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) and a Wegmans Food Market Brand Big Hawaiian bun.