Postprandial Lipid Metabolism in Patients With Hypertriglyceridemia and Normo-lipidemic Controls: Medium Chain Fatty Acids (MCT) in Comparison to Long-chain, Saturated Fatty Acids (SFA) and Mono-unsaturated Fatty Acids (MUFA)

Ludwig Maximilian University of Munich

Status: Completed

Conditions: Hypertriglyceridemia

Treatments: Other: MUFA; Other: SFA; Other: MCT

Study type: Interventional

Funder types: Other

Identifiers

NCT03846908

MCT-HTG

Details and patient eligibility

About

Postprandial lipid metabolism will be evaluated in patients with hypertriglyceridemia and normo-lipidemic controls; different fats will be used (saturated fatty acids, mon-unsaturated fatty acids and medium chain fatty acids) for the oral fat challenge.

Enrollment: 13 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• hypertriglyceridemia (150 mg/dl-900 mg/dl)

Exclusion criteria

• Lipid lowering drugs or indication for Lipid lowering drugs
• LDL-cholesterol > 190 mg/dl
• Diabetes mellitus

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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13 participants in 3 patient groups

MCT

Experimental group

Description:

subjects start with MCT fat load

Treatment:

Other: MCT

Other: MUFA

Other: SFA

SFA

Experimental group

Description:

subjects start with SFA fat load

Treatment:

Other: MCT

Other: MUFA

Other: SFA

MUFA

Experimental group

Description:

subjects start with MUFA fat load

Treatment:

Other: MCT

Other: MUFA

Other: SFA