Postprandial Response to Almond Consumption in Overweight Hispanic Pregnant Women

UCSF Benioff Children's Hospital Oakland

Status: Completed

Conditions: Diabetes, Gestational

Treatments: Other: Bagel; Other: Cream Cheese; Other: Almond Butter

Study type: Interventional

Funder types: Other

Identifiers

NCT01919476

CHO17-ABC

Details and patient eligibility

About

Currently, about one third of all women entering pregnancy are obese. The prevalence of metabolic disorders during pregnancy has increased concurrently with the rise in maternal obesity. Although dietary interventions are used routinely to reduce metabolic disease in non-pregnant obese individuals, no specific dietary advice is provided to obese, pregnant women unless they develop gestational diabetes mellitus. In this study, the investigators will specifically assess the effect of replacing dairy fats with almonds in a breakfast meal on the postprandial metabolic response. This cross-over, randomized control trial will examine the postprandial metabolic response to 0 or 2 oz of almonds in standardized test meals in pregnant Hispanic women with prepregnancy BMI between 25 and 40. Hispanics are at higher risk for gestational diabetes and the metabolic syndrome. The investigators hypothesize that consuming almonds in place of dairy fat reduces the glycemic response and improves the postprandial lipid profile in these high-risk women.

Enrollment: 18 patients

Sex: Female

Ages: 19 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant Hispanic women
• Between 30 and 36 weeks gestation
• Prepregnancy BMI between 25 and 40

Exclusion criteria

• Diagnosis of gestational diabetes mellitus
• Preexisting diabetes mellitus
• Renal disease
• Thyroid disease
• Cardiovascular disease
• History of drug abuse
• Nut allergies

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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18 participants in 2 patient groups

Control Meal: Bagel, cream cheese

Active Comparator group

Description:

Control meal consists of bagel with cream cheese and apple juice.

Treatment:

Other: Bagel

Other: Cream Cheese

Almond Meal: Bagel, almond butter

Experimental group

Description:

Almond meal consists of bagel with almond butter and apple juice.

Treatment:

Other: Almond Butter

Other: Bagel