Postprandial Responses to Fish Intake (PREFish)

University of Sao Paulo

Status: Active, not recruiting

Conditions: Postprandial Metabolism; Postprandial Lipids Metabolism; Post-prandial Glycaemic Response

Treatments: Other: Assessment of postprandial metabolism after intake of different meat

Study type: Interventional

Funder types: Other

Identifiers

NCT06757608

69418723.6.0000.0067

Details and patient eligibility

About

Fish consumption has been increasing in recent decades due to consumer interest in the positive health effects of regular food intake, among other factors. Previous studies have described significant results on the acute consumption of fish products, favoring the reduction of triglycerides, total cholesterol, low-density lipoprotein, reduced insulin secretion, and increased plasma concentration of high-density lipoprotein during the postprandial period. Despite this scenario, studies investigating acute metabolic responses, such as postprandial physiological phenomena after consumption of the main fish species ingested by Brazilians, are still scarce. Thus, investigations of the acute effects of fish intake on postprandial metabolism may reveal new beneficial effects associated with this food group. The present proposal aims to compare the acute effects of the ingestion of two sources of fish and bovine protein on postprandial metabolism through the capillary blood sample collected within 5 hours after the ingestion of test meals, investigating hormones and inflammatory mediators and quantifying triglycerides, total cholesterol and non-esterified fatty acids and blood glucose, in addition to evaluating sensory aspects and satiety between different meals. It is expected to generate new data on postprandial physiology and investigate possible effects of fish ingestion that can contribute to public health management and healthy eating patterns.

Enrollment: 30 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults between 18 and 35 years and with a body mass index between 20 and 29 kg/m2.

Exclusion criteria

• Individuals with a vegetarian/vegan diet, a history of fish allergy, aversion to fish, used supplementation with n-3 polyunsaturated fatty acids or probiotics, who have a diagnosis of pregnancy, dyslipidemia, diabetes, inflammatory bowel disease, liver disease, who have undergone surgeries that alter the anatomy of the digestive tract (bariatric surgery or cholecystectomy, for example) and use of antimicrobial therapy in the 3 months before the study will not be allowed to participate.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

Tambaqui meat

Active Comparator group

Description:

Tambaqui (Colossoma macropomum) meat intake, 7g per BMI unit

Treatment:

Other: Assessment of postprandial metabolism after intake of different meat

Sardine meat

Active Comparator group

Description:

Sardine (Opisthonema oglinum) meat intake, 7g per BMI unit

Treatment:

Other: Assessment of postprandial metabolism after intake of different meat

Beef

Active Comparator group

Description:

Beef (Bos taurus) meat intake, 7g per BMI unit

Treatment:

Other: Assessment of postprandial metabolism after intake of different meat