Postural Control in Chronic Obstructive Pulmonary Disease (NEUROTIGUE P)

Intermunicipal Hospital Center Toulon

Status

Completed

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Treatments

Other: Evaluation of visual feedback on static balance

Other: Evaluation of cognitive task on static balance

Study type

Observational

Funder types

Other

Identifiers

NCT06863246

2025-CHITS-006

Details and patient eligibility

About

Postural control impairment is common in people with COPD (pwCOPD), which can increase the risk of falls and affect quality of life. However, the majority of existing studies examine this postural control in isolation, without taking into account the cognitive demands that occur during activities of daily living during which individuals are often required to perform a mental task while maintaining their balance. This research aims to fill this gap by studying how a cognitive task can influence postural control in pwCOPD. We hypothesized an impaired postural control in pwCOPD compared to healthy individuals, which would be exacerbated in presence of a cognitive task.

Full description

This observational study is based on the analyses of data (center of pressure displacement) recorded during the first visit of NEUROTIGUE study (NCT04028973).

Center of pressure (COP) displacement were recorded during 60s of static balance in four conditions (random order) :

Eyes open without cognitive task
Eyes open with cognitive task
Eyes closed without cognitive task
Eyes closed with cognitive task The cognitive task used was a working memory task : the 1-back task. COP displacement will be assess using a conjunction of parameters to provide a comprehensive understanding of postural control (e.g., amplitude, standard deviation, non-linear approaches).

Enrollment

36 patients

Sex

All

Ages

40+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

COPD patients :

GOLD II - III or IV
FEV1 <80% of predicted values
Men and women aged 40 years and over
French-speaking participant
BMI <30 kg / m²
Stable condition (i.e. without exacerbation) for more than 15 days
Able to express their consent in writing prior to any participation in the study
Affiliates or beneficiaries of a social security
Minimum score of 26 on the MMSE questionnaire of 3 months or less

Healthy volunteers :

Men and women aged 40 years and over
French-speaking participant
BMI <30 kg / m²
No known chronic respiratory, cardiovascular, metabolic, renal or neuromuscular pathologies
Able to express their consent in writing prior to any participation in the study
Affiliates or beneficiaries of a social security
Minimum score of 26 on the MMSE questionnaire of 3 months or less

For all participants :

-Subject who has not objected to the reuse of data collected

Exclusion criteria

COPD patients :
Alcoholism, i.e. > 21 glasses a week for men and >14 glasses a week for women
Psychiatric pathologies or antecedent of behavioral disorders
Patients treated with oral or systemic corticosteroids (> 0.5 mg / kg / day for > 7 days)
Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
Severe vision or hearing problems not corrected
Patient oxygen dependent
Patients in exclusion period from another research protocol
Pregnant women (known pregnancy) or lactating women
Patient deprived of liberty by a judicial or administrative decision
Patient subject to a legal protection measure or unable to express their consent
Patient who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
Patient unable to follow study procedures and to respect visits throughout the study period
Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study

Healthy volunteers:

Alcoholism, i.e. > 21 glasses a week for men and >14 glasses a week for women
Psychiatric pathologies or antecedent of behavioral disorders
Patients treated with oral or systemic corticosteroids (> 0.5 mg / kg / day for > 7 days)
Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
Severe vision or hearing problems not corrected
Subjects in exclusion period from another research protocol
Pregnant women (known pregnancy) or lactating women
Regular physical activity with a frequency greater than 3 sessions per week
Participant deprived of liberty by a judicial or administrative decision
Participant subject to a legal protection measure or unable to express their consent
Participant who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
Participant unable to follow study procedures and to respect visits throughout the study period
Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study