Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients

The University of Texas System (UT)

Status and phase

Withdrawn

Phase 2

Phase 1

Conditions

Hypertension

Pre-hypertension

Treatments

Drug: Potassium Chloride

Drug: Potassium, Magnesium, Citrate

Study type

Interventional

Funder types

Other

Identifiers

NCT01074918

012007-080

Details and patient eligibility

About

The goal of this study is to compare the effects of Potassium Magnesium Citrate to Potassium Chloride on blood pressure among patients with pre-hypertension or mild hypertension. We will also test whether Potassium Magnesium Citrate increases excretion of large amounts of sodium in the urine.

Sex

All

Ages

21 to 95 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age greater than 21 years
BMI > 18.5 kg/m2 and < 40 kg/m2
Prehypertension and mild hypertension: BP systolic 120-159 mmHg, diastolic 80-95 mmHg
Must agree to limit lifestyle changes including: 1) embarking on a new exercise or weight reduction program 2) altering alcohol intake during the trial.

Exclusion criteria

Taking blood pressure lowering medication
Diabetes mellitus
Renal disease
Active cardiac disease
Active liver disease
Chronic diarrhea
Chronic NSAID use
Active or suspected drug use
Uncontrolled psychiatric disease
HIV infection
Missed more than 20% of clinic visits in the last yr
Prescription of diuretics for any reason
A patient taking nutritional supplements including multivitamins that is unwilling to discontinue them,\
Consumption of greater than 14 alcoholic beverages per week