Potential Adverse Developmental and Nutritional Consequences of Helicobacter Pylori Infection in Israeli Children

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Iron Deficiency Anemia; Child Development; Helicobacter Pylori Infection

Study type: Observational

Funder types: Other

Identifiers

NCT02654197

HYMC-0093-15

Details and patient eligibility

About

The investigators believe that there is an association between H. pylori infection and nutritional status and between H. pylori infection and cognitive development. The current study will examine this association in Israeli children, aged 6-12 years.

Enrollment: 600 estimated patients

Sex: All

Ages: 6 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Informed consent by parents/guardians and children

Exclusion criteria

• Growth retardation history
• History of prior therapy for H. pylori irradiation
• Hematological disorders
• Developmental delays

Trial design

600 participants in 2 patient groups

H.pylori positive children

Description:

Healthy children, 6-12 years old, will undergo screening for H. pylori infection by measuring anti-H. pylori and CagA IgG antibodies in the serum. The status of H. pylori infection will be confirmed using breath test (UBT). Children will be classified as i) H. pylori negative, if they test negative on UBT ii) H. pylori positive- CagA negative, if they test positive on UBT, but lack serum CagA IgG antibodies iii) H. pylori positive- CagA positive, if they are positive for H. pylori on UBT and CagA IgG antibodies.

H.Pylori negative children

Description:

Healthy children, 6-12 years old, will undergo screening for H. pylori infection by measuring anti-H. pylori and CagA IgG antibodies in the serum. The status of H. pylori infection will be confirmed using breath test (UBT). Children will be classified as i) H. pylori negative, if they test negative on UBT ii) H. pylori positive- CagA negative, if they test positive on UBT, but lack serum CagA IgG antibodies iii) H. pylori positive- CagA positive, if they are positive for H. pylori on UBT and CagA IgG antibodies.