Potential Beneficial Effects of Resveratrol

University of Aarhus

Status: Completed

Conditions: Obesity; Metabolic Syndrome

Treatments: Dietary Supplement: Resveratrol; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01150955

M-20100058

Details and patient eligibility

About

We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.

Full description

The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.

Enrollment: 24 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI > 30 kg/m2
• Otherwise healthy
• Written informed consent

Exclusion criteria

• Any disease
• Alcohol dependency
• Allergy to trial medication
• Present or previous malignancy
• Participation in other clinical trials within three months before randomization

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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24 participants in 2 patient groups, including a placebo group

Resveratrol

Active Comparator group

Description:

Dietary supplement of resveratrol 500 mg three times a day over five weeks.

Treatment:

Dietary Supplement: Resveratrol

Placebo

Placebo Comparator group

Treatment:

Other: Placebo