Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Acute Coronary Syndrome

Shanghai Jiao Tong University logo

Shanghai Jiao Tong University

Status

Unknown

Conditions

Acute Coronary Syndrome

Study type

Observational

Funder types

Other

Identifiers

NCT02755207
XH-16-003

Details and patient eligibility

About

The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for suspected ACS patients at the emergency department (ED) and intensive care unit (ICU).

Full description

The present study is a single-center, prospective diagnostic study among patients presenting to the ED or ICU within 24 h of onset of chest pain suggestive of suspected ACS. We propose to construct the biobank of ACS and evaluate the potential diagnostic value of circulating microRNAs compared with cTnI for suspected ACS patients. All the patients are to be followed up for 6 months. Final diagnosis was made by an expert panel cardiologist, based on all available clinical information including cTnI measurements, ECG, coronary angiography, cardiac exercise tests and information from hospital discharge letters. The concentrations of microRNAs will be evaluated by quantitative reverse transcription PCR, using highly specific primers and hybridization probes.

Enrollment

100 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Suspected ACS patients (STEMI, NSTEMI, and UA):

Age>18 years; Informed consent.

Exclusion criteria

Patients who will undergo immediate PCI; Pregnant and lactating women; Patients with mental disorders; Patients are using other experimental drugs; Refusal to provide informed.

Trial design

100 participants in 2 patient groups

Suspected ACS group
Description:
Patients admitted to the hospital with the diagnosis of ACS
Blank control group
Description:
Patients admitted to the hospital without the diagnosis of ACS

Trial contacts and locations

1

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Central trial contact

bin he; huimin cao

Data sourced from clinicaltrials.gov

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