Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Sepsis-induced Myocardial Injury

Shanghai Jiao Tong University

Status: Unknown

Conditions: Sepsis-induced Myocardial Injury

Study type: Observational

Funder types: Other

Identifiers

NCT02835573

XH-16-018

Details and patient eligibility

About

The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for the patients of sepsis-induced myocardial injury at the emergency department (ED) and intensive care unit (ICU).

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Diagnosis of sepsis:SOFA score increase >=2 at baseline level induced by infection.
2. Suspected myocardial injury,including 1 as follows at least:Low blood pressure or using vasoactive drugs; ECG changes(ST segment changes or pathological Q wave); Troponin elevation(> 0.5 μg/L); BNP elevation(> 4670pg/ml); Echocardiography: cardiac function decline(EF<50%).

Exclusion criteria

1. Skeletal muscle damage (induced by orthopedics, vascular surgery or trauma surgical disease, surgery);
2. Pregnant and lactating women;
3. Patients with mental disorders;
4. Patients are using other experimental drugs;
5. Refusal to provide informed consent

Trial design

100 participants in 2 patient groups

Sepsis-induced myocardial injury group

Description:

Patients admitted to the hospital with the diagnosis of Sepsis-induced myocardial injury

Blank control group

Description:

Patients admitted to the hospital without the diagnosis of Sepsis-induced myocardial injury