Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department (ADD-ED)

The Chinese University of Hong Kong

Status: Enrolling

Conditions: Aortic Dissection

Study type: Observational

Funder types: Other

Identifiers

NCT06065306

CREC 2022.631

Details and patient eligibility

About

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are:

• To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection
• To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection
• To study the association between plasma levels of selected biomarkers and clinical outcomes

Enrollment: 47 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years

• Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit

• Confirmed AD

  • the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first
  • The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.

Exclusion criteria

• Age <18 years old
• Pregnancy
• Surgery or stenting performed before recruitment

Trial design

47 participants in 2 patient groups

AD

Description:

Patient aged greater than 18, presented to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit and confirmed AD.

Healthy

Description:

Patients attending ED who do not have coronary disease, hypertension or aortic disease would be identified as healthy control.