Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis

IRCCS SYNLAB SDN

Status: Enrolling

Conditions: Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes

Treatments: Diagnostic Test: lncRNA signature analyses

Study type: Observational

Funder types: Other

Identifiers

NCT06337227

2/22

Details and patient eligibility

About

The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.

Enrollment: 3 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex;
• Patients without atherosclerosis undergoing surgical procedure for endocarditis;
• Patients who will have signed informed consent

Exclusion criteria

• Patients for whom biological material cannot be recovered for study purposes;
• Patients who refuse to participate in the study

Trial design

3 participants in 3 patient groups

atherosclerosis and calcific aortic stenosis with diabetes patients

Treatment:

Diagnostic Test: lncRNA signature analyses

atherosclerosis and calcific aortic stenosis without diabetes patients

Treatment:

Diagnostic Test: lncRNA signature analyses

Patients without atherosclerosis undergoing surgical procedure for endocarditis

Treatment:

Diagnostic Test: lncRNA signature analyses