PPAR, RXR, and VDR Expressions in Peri-implantitis

Tokat Gaziosmanpasa University

Status: Completed

Conditions: Periimplantitis; Periodontitis

Treatments: Other: Gingival biopsies

Study type: Observational

Funder types: Other

Identifiers

NCT04020146

Gaziosmanpasa University

Details and patient eligibility

About

ABSTRACT Objective: Periodontitis and peri-implantitis are the irreversible destructive diseases of the periodontal and peri-implant tissues. The present study aimed to determine the receptor expressions of Peroxisome proliferative-activated receptor (PPAR)-γ, Retinoid X receptor (RXR)-α, and Vitamin D receptor (VDR) in the diseased tissues around teeth and dental implants.

Methods: The study consisted of three groups as group 1; healthy controls (C, n=15), group 2; periodontitis patients with stage 3 grade B (P, n=15), and group 3; peri-implantitis patients (PI, n=15). Periodontal clinical parameters as the plaque index (PI), gingival index (GI) and clinical attachment levels (CAL) were recorded. Gingival biopsies were obtained from all participants and biopsy samples underwent histological tissue processing. Hematoxylin-eosin (H&E) and immunohistochemistry staining were performed. Total inflammatory cell counts and fibroblast cell density were evaluated on H&E-stained slides while PPAR-γ, RXR-α, and VDR were evaluated via immunohistochemistry.

Enrollment: 45 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy individuals
• periodontitis patients
• periimplantitis patients

Exclusion criteria

• smokers,
• systemically compromised patients

Trial design

45 participants in 3 patient groups

group 1;

Description:

healthy controls (C, n=15),

Treatment:

Other: Gingival biopsies

group 2

Description:

periodontitis patients with stage 3 grade B; (P, n=15)

Treatment:

Other: Gingival biopsies

group 3

Description:

peri-implantitis patients (PI, n=15).

Treatment:

Other: Gingival biopsies