PPI Guided Strategies for Prevention and Treatment of Intraoperative Hypotension

zhiqiang zhou

Status: Enrolling

Conditions: Intraoperative Hypotension

Treatments: Behavioral: Empirical strategies; Behavioral: PPI guided strategies

Study type: Interventional

Funder types: Other

Identifiers

NCT05792696

TJ-IRB20230247

Details and patient eligibility

About

Intraoperative hypotension is closely related to the poor prognosis of surgery. The study is focused on the effectiveness of maintaining normal peripheral perfusion index (PPI) on time-weighted average of hypotension during anesthesia.

Full description

Intraoperative hypotension is closely related to the poor prognosis of surgery. Hypotension decreased blood flow perfusion of organs, which lead to dysfunction of multiple organs, especially increasing serious complications such as cardio-cerebrovascular events and acute renal injury within 30 days after surgery. The aim of this study is to establish a set of strategies that can effectively prevent and treat intraoperative hypotension, so as to alleviate possible harm to patients from perioperative hypotension. The study is focused on the effectiveness of maintaining normal peripheral perfusion index (PPI) on time-weighted average of hypotension during anesthesia. The lower target mean arterial pressure (MAP) was higher than 65 mmHg. MAP less than 65 mmHg was defined as intraoperative hypotension between induction and tracheal extubation.

Enrollment: 54 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

65 years and older ASA Physical Status 1-3 general anesthesia arterial catheterization procedures last more than 2 hours communicate normally in Mandarin

Exclusion criteria

abnormal Allen's test higher target than 65 mmHg history of diabetes vascular diseases arrhythmia cardiac function class II and above physical disability, unable to conduct PPI monitoring participated in other clinical studies in the past month

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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54 participants in 2 patient groups

PPI guided strategies

Experimental group

Description:

The decision making for prevention and treatment of hypotension was PPI guided to maintain the PPI between 1 and 3.

Treatment:

Behavioral: PPI guided strategies

conventional strategies

Other group

Description:

The decision making for prevention and treatment of hypotension dependent on the experience of anesthesiologist.

Treatment:

Behavioral: Empirical strategies