PPIO-006 Primary Tumor Resection for IVa NSCLC

A

Army Medical University of People's Liberation Army

Status

Completed

Conditions

Non-small-cell Lung Cancer (NSCLC)

Treatments

Procedure: Primary tumor resection or not

Study type

Observational

Funder types

Other

Identifiers

NCT06232967
Wei Guo

Details and patient eligibility

About

The goal of this mutli-center observational study is toinvestigate the impact of primary tumor resection (PTR) on the long-term survival of patients with non-small-cell lung cancer (NSCLC) and dry pleural dissemination (DPD). The main question it aims to answer is: whether primary tumor resection improve long-term survival of NSCLC patients with dry pleural dissemination.

Full description

Non-small-cell lung cancer (NSCLC) patients with dry pleural dissemination have poor survival rates and are generally contraindicated for surgery. Previous single-center retrospective studies have suggested that these patients may benefit from primary tumor resection (PTR). However, the evidence supporting PTR is still limited, especially in the era of targeted therapy. This study aimed to investigate the impact of PTR on the long-term survival of patients with NSCLC and DPD.

Enrollment

204 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

(1) pathologically confirmed primary NSCLC with malignant pleural dissemination, (2) no preoperative treatment, (3) age 80 years or younger, (4) clinicopathologic data and follow-up results were complete.

Exclusion criteria

(1) pleural effusion, contralateral lung metastasis or distant metastasis revealed preoperatively, and (2) with a history of other malignant disease.

Trial design

204 participants in 2 patient groups

Primary tumor resection (PTR group)
Description:
includes wedge resection, segmentectomy, or lobectomy.
Treatment:
Procedure: Primary tumor resection or not
Exploratory thoracotomy (ET group)
Description:
JSimply open and close surgery.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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