Pragmatic Analysis of Complex Radiotherapy Cases In Cancer of the Lung (PRACTICAL)

The Christie NHS Foundation Trust

Status: Active, not recruiting

Conditions: Lung Cancer (SCLC); Lung Cancer (NSCLC)

Study type: Observational

Funder types: Other

Identifiers

NCT07202260

CFTSP 230

Details and patient eligibility

About

This study focuses on improving care for people with lung cancer who face unusual or complex treatment situations.

Full description

By studying detailed patient data, researchers aim to find the best ways to treat these patients while reducing short- and long-term side effects. The findings will help refine radiotherapy treatments, ensuring they are as safe and effective as possible. Additionally, the results will provide doctors with better information to help patients understand the potential risks and benefits of their treatment options.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Complex patients with lung cancer undergoing radiotherapy in one of the following groups;

• Rare histology
• Disease invading vascular structures
• Co-existing interstitial lung disease (ILD)
• Radical re-irradiation
• Oligopersistent/oligoprogressive disease on immunotherapy or targeted therapies.

Exclusion Criteria:

• Include patients with stage IV disease who are receiving non-curative intent radiotherapy
• There are no exclusion criteria relating to upper age limit or comorbidities.

Trial design

80 participants in 5 patient groups

Patients with co-existing interstitial lung disease

Patients who undergo radiotherapy twice to the same area (reirradiation).

Patients with the less common or rare types of lung cancer

Patients with cancer invading large blood vessels.

Patients with oligopersistent/oligoprogressive disease on immunotherapy or targeted therapies.