Pre-eclampsia and Biochemical Markers (PET)

Assiut University

Status: Completed

Conditions: Detection of Preeclampsia Complications

Study type: Observational

Funder types: Other

Identifiers

NCT02665897

PET

Details and patient eligibility

About

In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who subsequently developed pre-eclampsia compared to the control group.

This correlates well with the endothelial damage that occurs during pre-eclampsia and thus NGAL can be considered as a promising marker in predicting both early and late onset pre-eclampsia. It may be required to combine one or more biomarker with NGAL to increase the precision, and sensitivity for detection of risk and reliability of using biomarkers for pre-eclampsia.

Enrollment: 90 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 20-40 years.
• Gestational age >20 weeks.

Exclusion criteria

• Patients with preexisting renal disease,hypertension, diabetes mellitus, gestational hypertension.
• Patients Refuse to participate in the study
• Patients already have complicated preeclampsia.

Trial design

90 participants in 3 patient groups

Eclampsia

Description:

pregnant women with eclampsia will be diagnosed by the occurrence of seizures on top of preeclampsia.

severe preeclampsia

Description:

pregnant women with severe preeclampsia will be diagnosed according to blood pressure ≥160/110 mmHg with proteinuria detection by boiling method +3,+4.

healthy

Description:

matched normotensive pregnant women.