Pre-emptive Analgesia Effect in Different Psycho-emotional Status Patients During Lower Third Molar Surgical Extractions

Lithuanian University of Health Sciences

Status: Completed

Conditions: Pre-emptive Analgesia in Different Psycho-emotional Status Patients

Treatments: Other: No drug; Drug: Glucose; Drug: Ibuprofen 400 mg and Acetaminophen 500 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT04202224

5995

Details and patient eligibility

About

To increase the effectiveness of pain control, it is recommended to use drugs before the pain onset, therefore the pre-emptive analgesia method is considered as a method, which allows decreasing the post-operative pain to minimum. Previous studies evaluated effectiveness of pre-emptive analgesia but no relation to psycho-emotional status was addressed. Our authors believe that the effect of pre-emptive analgesia may vary based on different psycho-emotional status.

45 volunteers who needed extraction of lower third molars were examined and enrolled in the study (study group - 15; placebo - 15; control - 15 volunteers). Ibuprofen 400mg together with 500mg paracetamol was used for pre-emptive analgesia. Difficulty of the operation, heart rate measurements and operation protocol were documented. Surgeon filled his questionnaire after the procedure. Patients on consultation, operation day and 10 days postop. filled a questionnaire which consisted of general, special and pain evaluation sections. Less favorable psycho-emotional status correlated with more severe pain 6h after operation. This relation was mostly expressed in the control group. Psycho-emotional status of placebo patients was accounted for bigger analgesic consumption frequency. Postoperative pain in study group was minimal compared to other groups. Pre-emptive analgesia enhances patient's psycho-emotional status and sustains postoperative pain control during lower third molar surgical extractions.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult patients;
• Indications for mandibular third molar removal.

Exclusion criteria

• Presence of NSAID usage;
• Acute inflammation in operating site;
• General diseases that might negatively influence the outcomes of operation, such as epilepsy, unstable neurological condition;
• Anticoagulant usage;
• Diabetes mellitus;
• Cardiovascular diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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45 participants in 3 patient groups, including a placebo group

Study

Experimental group

Description:

Receives pre-emptive analgesia 30min. prior to third molar extraction. NSAID: Ibuprofen 400mg and Acetaminophen 500mg/

Treatment:

Drug: Ibuprofen 400 mg and Acetaminophen 500 mg

Placebo

Placebo Comparator group

Description:

Receives glucose tablets as pre-emptive analgesia 30min. prior to third molar extraction.

Treatment:

Drug: Glucose

Control

Active Comparator group

Description:

Receives no medication prior to third molar extraction.

Treatment:

Other: No drug