Pre-Emptive Analgesia Efficacy of Etoricoxib for Postoperative Pain

K

Khon Kaen University

Status and phase

Completed
Phase 3

Conditions

Total Pain Relief Over 8 Hr(TOPAR8)
Post Transabdominal Hysterectomy
Post-Operative Morphine Consumption
a Single-Dose of Etoricoxib

Treatments

Drug: a single-dose of Etoricoxib before induction of anesthesia

Study type

Interventional

Funder types

Other

Identifiers

NCT00149253
Faculty of Medicine,KhonKaenU
acute pain service

Details and patient eligibility

About

Taken together, studies of the value of pre-emptive analgesia are inconclusive. This randomized, double-blind, dose-ranging, placebo-controlled study was therefore designed to test that a reduction in post-operative morphine consumption can be achieved by a single-dose of etoricoxib before induction of anesthesia.

Full description

Patients undergoing transabdominal hysterectomy were randomized to a group taking a single dose (orally) of etoricoxib 120 mg (n = 18), etoricoxib 180 mg (n = 17) or placebo (n = 15) 2 hours before surgery under the same standardized general anesthesia. At the post-anesthetic care unit, intravenous morphine titration was given before starting self-controlled analgesia (PCA) device. Morphine consumption, pain relief score, sedative score, global evaluation score, and side-effects were recorded at 1, 2, 4, 8 and 24 h post-operatively. The primary end points were morphine consumption within 24-hr post-operatively and total pain relief over 8 h (TOPAR8). Patient global satisfaction was also assessed.

Sex

Female

Ages

15 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

The ASA I or II patients undergoing elective transabdominal hysterectomy with general anesthesia

Exclusion criteria

  • Patients with history of opioid addiction or chronic pain
  • Allergy to other nonsteroidal anti-inflammatory, or asthma
  • Concomitant use of tricyclic antidepressants, opioid analgesics, antihistamines, tranquilizers, hypnotics, sedatives, or systemic corticosteroids
  • Those unable to understand the principle of patient-controlled analgesia(PCA) device were excluded from the study

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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