Pre-emptive Analgesia Using Nebulized Ketamine Versus Nebulized Dexmedetomidine in Endoscopic Nasal Surgeries

Sohag University

Status: Enrolling

Conditions: Nose Diseases

Treatments: Drug: Ketamine; Drug: 0.9%sodium chloride; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT07056582

Soh-Med--25-4-08MS

Details and patient eligibility

About

this study aims to compare the efficacy of pre-emptive nebulized ketamine versus nebulized dexmedetomidine for post operative pain relief in endoscopic nasal surgery

Enrollment: 105 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients between the ages of 20 and 60,
• both sexes,
• American Society of Anesthesiologists physical status I to II
• BMI ≥18≤30 kg/m²

Exclusion criteria

• Patient refusal.
• patients with advanced respiratory, renal, hepatic, neurological, or psychiatric disease, pregnant or nursing women.
• patients with a history of allergies to any study drugs.
• patients who had used central nervous system depressants or analgesics within the previous 24 hours.
• patients with hypertension, hypotension, or bradycardia.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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105 participants in 3 patient groups, including a placebo group

group D : will receive dexmedetomidine

Active Comparator group

Description:

Patients will receive nebulized dexmedetomidine 50 μg (0.5 ml +normal saline 0.9% up to 3 ml) 15 minutes prior to the onset of surgery.

Treatment:

Drug: Dexmedetomidine

group K : will receive ketamine

Active Comparator group

Description:

patients will receive nebulized ketamine 50 mg (1 ml + normal saline 0.9%up to 3 ml) 15 minutes prior to the onset of surgery.

Treatment:

Drug: Ketamine

group C: will receive .9% saline

Placebo Comparator group

Description:

Patients will receive nebulized normal saline 0.9% (3 ml) 15 minutes prior to the onset of surgery.

Treatment:

Drug: 0.9%sodium chloride