Pre-emptive US Guided Superior Hypogastric Plexus Block in Pelvic Cancer Surgeries : a Randomized Double-Blinded Study

National Cancer Institute, Egypt

Status: Unknown

Conditions: Analgesia

Treatments: Procedure: Superior Hypogastric Plexus Block

Study type: Interventional

Funder types: Other

Identifiers

NCT04732234

IORG0003381-AP2006-50103

Details and patient eligibility

About

The superior hypogastric plexus (SHP) is a retroperitoneal structure with a predominance of afferent sympathetic nerve fibers. The perception of central pelvic pain is thought mainly to involve transmission through this plexus. Therefore, blocking or of SHP has been used to treat pelvic pain.

Full description

Ultrasound guided superior hypogastric plexus block there is 2 equal groups:

Group S (SHPB group 18 patients) ultrasound guided SHPB is done after induction of balanced general anesthesia (fentanyl, propofol and rocuronium) using 20 ml Bupivacaine 0.5% before skin incision, Group C (Control group 18 patients) in which same technique will be done but using normal saline 0.9% instead of bupivacaine. Patients of both groups will receive patient controlled analgesia using morphine with continous background infusion of morphine 1.5 mg/h with adding granisterone 2mg/60 ml and ability to give bolus of 0.5 mg morphine on demand.

• Dosing and administration; Group S (SHPB group 18 ultrasound guided SHPB ) using 20 ml Bupivacaine 0.5% before skin incision.

Group C (Control group 18 patients) in which same technique will be done but using normal saline 0.9%

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA II,III.
• Patients undergoing pelvic surgeries.

Exclusion criteria

• Patients refusal,
• Coagulopathy,
• Infection.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

( Group A)

Active Comparator group

Description:

ultrasound guided superior hypogastric plexus block using 20 ml Bupivacaine 0.5% before skin incision.

Treatment:

Procedure: Superior Hypogastric Plexus Block

(Group B)

Placebo Comparator group

Description:

ultrasound guided superior hypogastric plexus block using 20 ml normal saline 0.9% instead of bupivacaine.

Treatment:

Procedure: Superior Hypogastric Plexus Block