Pre-exposure Prophylaxis: A Miracle Drug or a Moral Hazard

New York University (NYU)

Status: Completed

Conditions: Sexually Transmitted Diseases; Gonorrhea; Syphilis; Chlamydia

Treatments: Drug: PrEP

Study type: Observational

Funder types: Other

Identifiers

NCT04325555

097-2018

Details and patient eligibility

About

The investigators study the behavioral consequences of Pre-exposure Prophylaxis or PrEP on sexual health behaviors, sexual health outcomes, and partner selection preferences. The study collects observational, self-reported data on PrEP status, PrEP taking-history, PrEP adherence over the last 30 days, STD diagnosis history dating back to January 2015 up to December 2019, sexual health behaviors (e.g., positioning, number of lifetime/recent partners, condom adherence etc.), and various demographic characteristics. The survey finishes with a conjoint experiment which asks respondents to select between two potential partners, and follow-up question about each profiles. Potential partners' characteristics include recreational drug use and condom adherence. Recruitment is conducted via running an ad on Facebook in New York, London, Toronto and Sydney for comparative purposes, as these metro areas have varying levels of PrEP use and accessibility.

Full description

See statistical analysis plan.

Enrollment: 2,647 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years or above
• living in the London, New York, Toronto or Sydney metro area
• self-reported sex at birth is male
• reported ever having sex with a male

Exclusion criteria

• not meeting the inclusion criteria

Trial design

2,647 participants in 1 patient group

Respondents on PrEP

Description:

On PrEP status will be operationalized in multiple ways, and sensitivity analyses will be conducted using multiple definitions as a result of the self-reported nature of the study. 1. Respondents "on PrEP" are respondents who reported that they are currently on PrEP 2. Respondents "on PrEP" are respondents who reported to have ever been on PrEP 3. When respondents are used as their own controls, years on PrEP will be those in which they reported to have been on PrEP for at lest 6 months, and PrEP initiation will be the first such year A comparison group will be constructed by matching on a variety of characteristics, when this method is applied. Most importantly, age, and STD testing frequency among others, which influence the likelihood of being on PrEP and via that avenue sexual practices, as well as the likelihood of detecting STDs (i.e., ascertainment bias). In other models adjustments will be made for these factors.

Treatment:

Drug: PrEP