Pre-operative 5% Dextrose Infusion & PONV

Cairo University (CU)

Status: Completed

Conditions: Nausea, Postoperative

Treatments: Dietary Supplement: Dextrose 5%, normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT05947981

MS-206-2022

Details and patient eligibility

About

With this study, we aim to compare the efficacy of pre-operative dextrose-containing fluid infusion with other fluid for the prevention of PONV in middle ear surgeries.

Full description

We hypothesized that maintenance of stable level of blood glucose in addition to adequate hydration through preoperative intravenous dextrose 5% infusion will have a rule in decreasing the incidence and severity of PONV; as it reduces insulin resistance and decreases gastric acid secretion; which may contribute to PONV.

Enrollment: 105 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA physical status I and ll.
• Patients undergoing middle ear surgeries, mastoidectomy, or tympanoplasty

Exclusion criteria

• history of dependence or use of antiemetics
• history of motion sickness
• presence of psychiatric illness
• pregnant and lactating women
• cardiovascular disorders (Ischemic heart diseases, congestive heart failure and valvular diseases)
• Diabetic patients

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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105 participants in 3 patient groups, including a placebo group

Control group

No Intervention group

Description:

Patients will be fasted and not receiving any pre-operative fluids

Dextrose group

Active Comparator group

Description:

Patients will take 100ml/HR of clear fluids (apple juice) during the fasting hours till 2 hrs before the operation and will receive dextrose 5% infusion at a rate of 1ml/kg/h 2hrs before the operation and till the end of the operation

Treatment:

Dietary Supplement: Dextrose 5%, normal saline

Normal saline group

Placebo Comparator group

Description:

Patients will take 100ml/HR of water during the fasting hours till 2 hrs before the operation and will receive normal saline 0.9% at a rate of 1ml/kg/h (group NS) intravenously (IV)2hrs before the operation and till the end of the operation

Treatment:

Dietary Supplement: Dextrose 5%, normal saline