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Pre-operative Evaluation of Kidney & Pancreas Transplant Patients

University of Nebraska logo

University of Nebraska

Status

Completed

Conditions

Pancreas Transplantation
Kidney Transplantation

Treatments

Procedure: Dobutamine Stress Echocardiogram

Study type

Interventional

Funder types

Other

Identifiers

NCT00580437
0142-03-EP

Details and patient eligibility

About

Examine the clinical utility of the dobutamine stress contrast echoes and angiograms obtained routinely in the evaluation of patients prior to kidney or pancreas transplantation.

Full description

Although there is an increasing quantity of data demonstrating the value of stress echo in risk stratifying patients for cardiac risk prior to major non-cardiac surgery, the current clinical practice utilized for assessing patients being evaluated for kidney or pancreas transplantation is both a stress echocardiogram and a coronary angiogram. This gap in opinion appears to be a concern on the part of both nephrologists, endocrinologists, and surgeons that the stress echocardiogram may miss significant angiographic disease that could result in major post-operative complications in this high-risk subgroup of patients (unstable angina, non-fatal infarction, or death).

Enrollment

150 patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients who are being evaluated for a kidney and or pancreas transplant and scheduled for a dobutamine stress echocardiogram and a coronary angiogram will be eligible to participate

Exclusion criteria

  • Patients with unstable angina at the time of their evaluation, or who have a severe underlying cardiomyopathy or valve disease will be excluded.

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

150 participants in 1 patient group

Arm 1
Experimental group
Description:
stress echocardiograms involving the use of intravenous Optison or Definity contrast agents to improve endocardial definition
Treatment:
Procedure: Dobutamine Stress Echocardiogram

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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