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This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. Blood samples will be collected before and after the supplementation period to analyze markers of muscle damage, including creatine kinase and lactate dehydrogenase. This study aims to provide insight into the efficacy of short-term, time-specific creatine supplementation for enhancing performance and recovery.
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Inclusion criteria
Female, aged 18 to 25 years
Recreationally active (engaging in structured resistance training 3-4 times per week for the past 6 months)
Regular menstrual cycles (used for scheduling purposes)
Able and willing to provide informed consent
Agreement to maintain normal diet and training routines throughout the study
Exclusion criteria
History of musculoskeletal injury affecting lower or upper limbs within the past 6 months
Known allergy or intolerance to creatine or maltodextrin
Use of performance-enhancing substances or supplements within the last 30 days
Use of recovery modalities such as massage, cryotherapy, or compression garments during the study period
Current use of anti-inflammatory medication
Pregnancy or breastfeeding
Inability to comply with study protocol or scheduled assessments
Primary purpose
Allocation
Interventional model
Masking
24 participants in 2 patient groups, including a placebo group
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Central trial contact
Morteza Jourkesh, PhD; Caglar Soylu, phD
Data sourced from clinicaltrials.gov
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