Pre-treatment With Methylene Blue Prevent Peri-operative Reduced Systemic Vascular Resistance

Army Medical University

Status: Unknown

Conditions: Obstructive Jaundice

Treatments: Drug: Methylene Blue

Study type: Interventional

Funder types: Other

Identifiers

NCT03406676

MZK002

Details and patient eligibility

About

To explore the effects of pre-treatment with methylene blue on reduced perioperative vascular resistance in patients with obstructive jaundice.

Full description

Hemodynamic characteristics of patients with obstructive jaundice are high cardiac output, low peripheral vascular resistance. The molecular basis for this feature is the increased production of NO. Methylene blue can increase peripheral resistance, the mechanism is: methylene blue is an oxidoreductase inhibitor, can inhibit the increased production of NO in the vascular endothelium, thereby increasing peripheral vascular resistance.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged between 18-60 years;
2. American Society of Anesthesiologists（ASA） grade I~III;
3. TBIL>ULN and TBA>ULN; The patients with obstructive jaundice.

Exclusion criteria

1. Organs dysfunction(heart,lungs and etc);
2. Mental disorders;
3. in other clinical trial.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

70 participants in 2 patient groups

Methylene blue

Experimental group

Description:

2mg / Kg of methylene blue in volume of 50ml is administrated I.V before anesthesia induction.

Treatment:

Drug: Methylene Blue

saline

No Intervention group

Description:

50ml of saline is administrated I.V before anesthesia induction.