Pre-washing the Catheter With a Culture Medium Before Intrauterine Insemination

Eskisehir Osmangazi University

Status: Unknown

Conditions: Infertility

Treatments: Procedure: Pre-washed catheter vs. Unwashed catheter in the intrauterine insemination

Study type: Interventional

Funder types: Other

Identifiers

NCT04736459

2222392979

Details and patient eligibility

About

The aim of the study to evaluate the possible effect of washing the insemination catheters before intrauterine insemination on the pregnancy outcomes.

We know that washing the catheters are already washed in the case of embryo transfer for assisted reproductive techniques. Based on this knowledge, we also constituted the hypothesis which is about the impact of washing the catheter on the gametes and embryos. The pre-washing the catheter before intrauterine insemination may provide higher pregnancy results.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• at least 1-year infertility
• at least one patent fallopian tube confirmed by hysterosalpingography (HSG) or laparoscopy
• ovulatory menstrual cycles
• suitable semen analysis according to the World Health Organization (WHO) criteria for intrauterine insemination

Exclusion criteria

• bilateral tubal occlusion
• mild or severe endometriosis
• day 3 serum FSH (follicle-stimulating hormone) > 13 IU/L
• abnormal thyroid function tests, hyperprolactinemia
• total motile sperm count (TMSC) < 5 millions or severe teratospermia (<4% normal forms) following semen preparation
• more than 3 follicles above the size of 17mm on the day of ovulation triggering

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

Washed Catheter

Experimental group

Description:

Washed catheter arm: will be washed with culture medium before insemination

Treatment:

Procedure: Pre-washed catheter vs. Unwashed catheter in the intrauterine insemination

Unwashed Catheter

Sham Comparator group

Description:

Unwashed catheter arm: will not be washed with culture medium.

Treatment:

Procedure: Pre-washed catheter vs. Unwashed catheter in the intrauterine insemination