Preanalgesic Effect of Gabapentin in Total Knee Repair

Texas Health Resources

Status: Completed

Conditions: Pain

Treatments: Drug: Placebos; Drug: Gabapentin

Study type: Interventional

Funder types: Other

Identifiers

NCT00279487

P768

Details and patient eligibility

About

The purpose of this study is to determine whether gabapentin, as a one time administration prior to a total knee replacement procedure, has opioid sparing effects and a reduction in pain scores.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing total knee replacement who received pain management by the following modality:

  • Intravenous patient-controlled analgesia (IV-PCA) opioid
  • Local femoral nerve block with 1.5% mepivacaine 20 ml and 0.5% ropivacaine 20 ml

Exclusion criteria

• Age < 18 years old

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

24 participants in 2 patient groups, including a placebo group

Arm 1

Active Comparator group

Description:

Patients will receive 1200mg gabapentin 1-2 hours prior to surgery.

Treatment:

Drug: Gabapentin

Arm 2

Placebo Comparator group

Description:

Patients will receive placebo 1-2 hours prior to surgery.

Treatment:

Drug: Placebos