Prebiotic Effect on Metabolites in Crohn's Disease

Catholic University (KU) of Leuven

Status: Completed

Conditions: Crohn Disease

Treatments: Dietary Supplement: Oligofructose enriched inulin; Dietary Supplement: Maltodextrin

Study type: Interventional

Funder types: Other

Identifiers

NCT01487759

ML4789

Details and patient eligibility

About

The purpose of this study is to investigate the influence of the prebiotic oligofructose enriched inulin on the metabolite pattern in Crohn's disease patients.

Enrollment: 67 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• crohn's disease

Exclusion criteria

• severe crohn's disease (harvey bradshaw index >12)
• pregnancy
• history of colectomy
• use of antibiotics 4-wks before start of the study
• use of sulfapyridine
• use of commercially available prebiotics and probiotics

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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67 participants in 2 patient groups, including a placebo group

Prebiotic

Active Comparator group

Treatment:

Dietary Supplement: Oligofructose enriched inulin

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Maltodextrin