Prebiotic Effects of a Polyphenol-rich Food Product

Iowa State University

Status: Completed

Conditions: Dysbiosis

Treatments: Other: Placebo beverage; Other: Cranberry beverage

Study type: Interventional

Funder types: Other

Identifiers

NCT03659240

18-303-00

Details and patient eligibility

About

The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.

Enrollment: 25 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 27-35 kg/m2
• High waist circumference (men >102 cm and women >88 cm)

Exclusion criteria

• Cigarette smoking
• Regular intensive exercise
• Pregnancy or lactation
• Chronic diarrhea, constipation, or other gastrointestinal complaint
• Diabetes mellitus, autoimmune disease, or other chronic disease known to alter the gut microbiota
• Use of medications that affect inflammation or the gut microbiota
• Use of prebiotics, probiotics, synbiotics, vitamins, or other dietary supplements known to affect the gut microbiota
• Aversion to cranberries
• Food allergies
• Lactose intolerance
• Vegetarianism

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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25 participants in 2 patient groups, including a placebo group

Cranberry beverage

Experimental group

Treatment:

Other: Cranberry beverage

Placebo beverage

Placebo Comparator group

Treatment:

Other: Placebo beverage